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. 2017 Dec 24;9(5):5588–5599. doi: 10.18632/oncotarget.23652

Figure 1. Importance of MMP2 and A2M interaction during aging identified by RNA-Seq based on NGS data.

Figure 1

(A) Brief scheme of NGS analysis from young, aged, and CR rat kidney. RNA-Seq technology based on Illumina Hiseq-2000 was utilized to investigate molecular changes during aging and CR. (B) Result of genes changed during aging and CR analyzed by identifying DEG. (C) Result of commonly changed genes during aging and CR. (D) Degree and centrality of commonly changed genes. The degree and centrality of A2M and MMP2 are highest among the commonly changed genes. (E) Result of PPI analysis among the commonly changed genes during aging and CR. Result shows the direct interaction of A2M-MMP2. The colors indicate the changes of gene expression by aging and CR. Gene expressions of A2M and MMP2 are both increased by aging and decreased by CR.