Figure 2. High levels of heparanase are associated with reduced survival of stage I breast cancer patients.

(A) Immunostaining. Stage I breast carcinomas were subjected to immunostaining applying anti-heparanase antibody. Shown are representative photomicrographs of cases exhibiting no staining of heparanase in the tumor cells (positive staining is detected in stromal cells; upper panels), weak (middle panels) or strong (lower panels) staining. (B) Kaplan-Meier survival analysis. The survival of patients was examined according to heparanase staining intensity. Note bad prognosis of stage I breast cancer patients that exhibit strong staining of heparanase (HR 4.52; p = 0.03).