Schematic illustration of the rod photoreceptor for wild type mice and BBS mutant mice. The BBSome is involved in protein trafficking along the axoneme. In Bbs8 and Bbs17 mutant mice, proteins are mislocalized. In a wild type mouse, STX3 and STXBP1 are located at the synapse and base of the cilium. Rhodopsin is localized to the discs. In addition, Prominin 1 is located at the base of the outer segment. In BBS mutant mice, STX3 and STXBP1 are found throughout the outer segment. Rhodopsin is found at the inner segment and outer nuclear layer. In addition, Prominin 1 is found throughout the outer segment.