Table 1. Host and tumor characteristics for PDX establishment in pancreatic cancer.
| Characteristics | All (n = 25, 100%) | PDX generation (n, %) | PDOX & PDHX generation (n, %) | ||||
|---|---|---|---|---|---|---|---|
| PDOX (n = 17, 68.0%) | PDHX (n = 18, 72.0%) | P value | both (n = 13, 52.0%) | none (n = 12, 48.0%) | P value | ||
| Age, y | |||||||
| mean (SD) | 61.8 ± 8.2 | 60.23 ± 8.51 | 62.17 ± 7.69 | 0.486 | 60.8 ± 8.07 | 63.1 ± 8.73 | 0.498 |
| Gender, n (%) | |||||||
| Female | 14 (56%) | 11 (31.4%) | 12 (34.3%) | 9 (36.0%) | 5 (20.0%) | ||
| Male | 11 (44%) | 6 (17.1%) | 6 (17.1%) | 0.903 | 4 (16.0%) | 7 (28.0%) | 0.238 |
| Type of operation, n (%) | |||||||
| PD | 19 (76%) | 12 (34.3%) | 13 (37.1%) | 8 (32.0%) | 11 (44.0%) | ||
| DP | 6 (24%) | 5 (14.3%) | 5 (14.3%) | 0.915 | 5 (20.0%) | 1 (4.0%) | 0.160 |
| Tumor size (cm) | |||||||
| mean (SD) | 3.35 ± 0.9 | 3.48 ± 1.01 | 3.40 ± 1.02 | 0.825 | 3.5 ± 1.10 | 3.3 ± 0.68 | 0.589 |
| Tumor differentiation, n (%) | |||||||
| WD | 1 (4%) | 1 (2.9%) | 1 (2.9%) | 1 (4.0%) | 0 (0%) | ||
| MD | 22 (88%) | 14 (40.0%) | 15 (42.9%) | 4 (40.0%) | 12 (48.0%) | ||
| PD | 2 (8%) | 2 (5.7%) | 2 (5.7%) | 0.997 | 2 (8.0%) | 0 (0%) | 0.207 |
| T stage, n (%) | |||||||
| T3 | 25 (100%) | 17 (48.6%) | 18 (51.4%) | 13 (52.0%) | 12 (48.0%) | ||
| N stage, n (%) | |||||||
| N0 | 5 (20%) | 4 (11.4%) | 5 (14.3%) | 3 (12.0%) | 2 (8.0%) | ||
| N1 | 20 (80%) | 13 (37.1%) | 13 (37.1%) | 0.774 | 10 (40.0%) | 10 (40.0%) | 0.689 |
| M stage, n (%) | |||||||
| M0 | 23 (92%) | 15 (42.9%) | 16 (45.7%) | 11 (44.0%) | 12 (48.0%) | ||
| M1* | 2 (8%) | 2 (5.7%) | 2 (5.7%) | 0.952 | 2 (8.0%) | 0 (0%) | 0.157 |
| p53, n (%) | |||||||
| normal | 7 (28%) | 5 (14.3%) | 4 (11.4%) | 3 (12.0%) | 4 (16.0) | ||
| inactivated | 18 (72%) | 12 (34.3%) | 14 (40.0%) | 0.627 | 10 (40.0%) | 8 (32.0%) | 0.568 |
| C-erbB-2, n (%) | |||||||
| normal | 18 (72%) | 14 (40.0%) | 14 (40.0%) | 10 (40.0%) | 8 (32.0%) | ||
| overexpressed | 7 (28%) | 3 (8.6%) | 4 (11.4%) | 0.735 | 3 (12.0%) | 4 (16.0%) | 0.568 |
| DPC 4, n (%) | |||||||
| normal | 14 (56%) | 11 (31.4%) | 9 (25.7%) | 7 (28.0%) | 7 (28.0%) | ||
| inactivated | 11 (44%) | 6 (17.1%) | 9 (25.7%) | 0.380 | 6 (24.0%) | 5 (20.0%) | 0.821 |
PD, pancreatico-duodenectomy; DP, distal pancreatectomy; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated; DPC4, deleted in pancreatic carcinoma locus 4. *All of the metastases were liver.