Table 2. Comparative analysis of the SNP mutations in cancer-related genes of patient-derived xenografts.

Gene(s) / No. of SNP sites	Group No.1				Group No.7				Group No.16				Group No.23
	PDOX/human		PDHX/human		PDOX/human		PDHX/human		PDOX/human		PDHX/human		PDOX/human		PDHX/human
	O	X	O	X	O	X	O	X	O	X	O	X	O	X	O	X
ACVR2A/39	39	0	39	0	39	0	39	0	39	0	39	0	39	0	39	0
APC/73	73	0	73	0	73	0	73	0	67	6	67	6	73	0	73	0
ARID1A/32	32	0	32	0	32	0	32	0	32	0	32	0	32	0	32	0
ATM/76	76	0	73	3	76	0	76	0	73	3	72	4	76	0	76	0
BCORL1/10	10	0	10	0	10	0	10	0	10	0	10	0	10	0	10	0
BRCA1/35	35	0	35	0	35	0	35	0	35	0	35	0	35	0	35	0
BRCA2/71	71	0	71	0	58	13	58	13	71	0	71	0	54	17	71	0
CALD1/166	166	0	166	0	166	0	166	0	166	0	166	0	132	34	166	0
DISP2/6	6	0	6	0	6	0	6	0	5	1	5	1	6	0	6	0
FBLN2/73	73	0	67	6	73	0	73	0	73	0	72	1	66	7	72	1
FBXW7/87	87	0	87	0	87	0	87	0	87	0	87	0	70	17	87	0
HIVEP1/139	139	0	138	1	139	0	139	0	111	28	110	29	139	0	139	0
ITPR3/91	90	1	91	0	91	0	91	0	90	1	91	0	91	0	91	0
JAG1/49	49	0	49	0	49	0	49	0	49	0	49	0	49	0	34	15
KALRN/539	538	1	539	0	539	0	539	0	539	0	539	0	539	0	467	72
KDM6A/84	84	0	84	0	84	0	84	0	84	0	84	0	84	0	84	0
KRAS/46	46	0	46	0	46	0	46	0	46	0	46	0	46	0	46	0
MACF1/187	187	0	187	0	171	16	187	0	187	0	187	0	187	0	187	0
MAP2K4/3	3	0	3	0	2	1	2	1	3	0	3	0	3	0	3	0
MLL3/122	122	0	122	0	122	0	122	0	122	0	122	0	122	0	122	0
MYCBP2/115	115	0	115	0	104	11	106	9	115	0	115	0	115	0	84	31
NBEA/391	391	0	391	0	336	55	336	55	391	0	391	0	327	64	391	0
NF2/43	43	0	36	7	43	0	43	0	43	0	43	0	43	0	43	0
PBRM1/50	50	0	50	0	50	0	50	0	50	0	50	0	35	15	50	0
PLXNB2/10	10	0	9	1	9	1	9	1	10	0	10	0	10	0	10	0
PTEN/48	48	0	48	0	48	0	48	0	48	0	48	0	42	6	48	0
RBM10/10	10	0	10	0	10	0	10	0	10	0	10	0	10	0	10	0
RNF43/43	43	0	40	3	36	7	36	7	40	3	40	3	43	0	43	0
SDK2/242	240	2	218	24	242	0	242	0	214	28	213	29	242	0	242	0
SETD2/50	50	0	50	0	50	0	50	0	50	0	50	0	42	8	50	0
SF3B1/13	13	0	13	0	13	0	13	0	13	0	13	0	13	0	13	0
SIN3B/20	20	0	15	5	20	0	20	0	20	0	20	0	20	0	15	5
SMAD3/158	158	0	158	0	158	0	158	0	109	49	109	49	158	0	91	67
SMAD4/24	24	0	23	1	19	5	20	4	24	0	24	0	23	1	14	10
SMARCA4/38	38	0	38	0	38	0	38	0	38	0	38	0	38	0	38	0
SPTB/99	99	0	99	0	99	0	99	0	76	23	76	23	99	0	99	0
TGFBR1/27	27	0	25	2	27	0	27	0	27	0	27	0	21	6	27	0
TGFBR2/101	101	0	86	15	101	0	101	0	101	0	101	0	85	16	101	0
TLE4/92	92	0	83	9	92	0	92	0	92	0	92	0	85	7	91	1
TP53/45	45	0	45	0	43	2	41	4	44	1	44	1	45	0	45	0
U2AF1/15	15	0	15	0	15	0	15	0	15	0	15	0	15	0	15	0
Total (%) N = 3562	3558 (99.9%)	4 (0.1%)	3485 (97.8%)	77 (2.2%)	3451 (96.9%)	111 (3.1%)	3468 (97.4%)	94 (2.6%)	3419 (96.0%)	143 (4.0%)	3416 (95.9%)	146 (4.1%)	3364 (94.4%)	198 (5.6%)	3360 (94.3%)	202 (5.7%)