Figure 4. DNA repair mutations are biomarkers for high tumor neo-antigen load, which is associated with increased TILs.

Neo-antigen count of tumors with (A) HR, (B) MMR, or (C) POLE mutations. Results are presented as mean ± SEM. (D) Percent of neo-antigen low (black bars) or high (gray bars) patients infiltrated by immune cell types (all immune cell types with P < 0.1 displayed). ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001.