Table 2. Genomic information of Ph-like ALL PDX samples.
PDX | Ph-like ALL Genomic Lesions | |
---|---|---|
CRLF2 | JAK2 | |
1 | IGH-CRLF2 | WT |
2 | P2RY8-CRLF2 | WT |
3 | P2RY8-CRLF2 | WT |
4 | IGH-CRLF2 | WT |
5 | IGH-CRLF2 | WT |
6 | IGH-CRLF2 | WT |
7 | IGH-CRLF2 | WT |
8 | P2RY8-CRLF2 | T875N |
9 | IGH-CRLF2 | R683G |
10 | IGH-CRLF2 | R683S |
11 | P2RY8-CRLF2 | R683G |
12 | IGH-CRLF2 | R683S |
13 | P2RY8-CRLF2 | R683S |
14 | P2RY8-CRLF2 | R683G |
15 | N/A | PAX5-JAK2 |
16 | N/A | ATF7IP-JAK2 |
PDX 13, 14 were confirmed strong Ph-like signature by microarray and prediction analysis of microarray, which reported previously as SJBALL021755 and SJBALL191 [3].