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. Author manuscript; available in PMC: 2018 Feb 15.
Published in final edited form as: Vaccine. 2017 Apr 14;35(21):2840–2847. doi: 10.1016/j.vaccine.2017.04.008

Figure 4. Cotton rat lung pulmonary histopathology after RSV/A challenge.

Figure 4

The lungs of Cotton rats in groups A-G were harvested 5 days after 1×105 RSV/A challenge. Lungs were formalin fixed, sectioned and H&E stained. Slides were scored on a 0-4 severity scale in a blinded manner. Scores were converted onto a 0-100% histopathology scale (0=no; 25=minimal, 50=mild; 75=moderate; 100=maximal inflammation). The parameters evaluated were peribronchiolitis (PB), perivasculitis (PV), alveolitis (A) and interstitial pneumonia (IP). Bars represent mean pathology scores + SEM (a). Representative lung H&E images non-treated animal (b), and 5 days post challenge from FI-RSV vaccinated animal (c), day 0 RSV/A infected animals (d) and from pGX2303 immunized animal from (e). Magnification x40.