Table 3.
Interaction on additive and multiplicative scale between smoking and other risk factors of liver cancer in Jiangsu study, 2003–2010
| Factors | case/control | Adjusted OR* (95% CI) |
SB-Adjusted OR (95% PI) |
Interaction | |
|---|---|---|---|---|---|
| Ever smoke | HBsAg positive | ||||
| No | No | 368/3248 | 1.00 | 1.00 | ROR: 1.64 (1.17–2.30) |
| No | Yes | 229/247 | 7.66 (6.05–9.71) | 7.23 (5.73–9.13) | RERI: 7.77 (3.81–11.73) |
| Yes | No | 321/2826 | 1.25 (1.03–1.52) | 1.24 (1.03–1.51) | AP: 0.50 (0.35–0.64) |
| Yes | Yes | 295/178 | 15.68 (12.06–20.39) | 14.25 (11.01–18.45) | S: 2.12 (1.53–2.94) |
| Ever smoke | Anti-HCV positive | ||||
| No | No | 592/3470 | 1.00 | 1.00 | ROR: 0.62 (0.13–3.05) |
| No | Yes | 6/22 | 1.55 (0.54–4.44) | 1.32 (0.57–3.05) | RERI: −0.61 (−2.93–1.71) |
| Yes | No | 612/2976 | 1.43 (1.20–1.70) | 1.42 (1.20–1.69) | AP: −0.45 (−2.55–1.66) |
| Yes | Yes | 5/31 | 1.37 (0.41–4.59) | 1.20 (0.48–2.97) | S: 0.38 (0.00–43.40) |
| Ever smoke | Ever drink alcohol | ||||
| No | No | 651/3128 | 1.00 | 1.00 | ROR: 0.90 (0.64–1.26) |
| No | Yes | 320/1113 | 1.88 (1.48–2.38) | 1.85 (1.46–2.33) | RERI: 0.08 (−0.47–0.64) |
| Yes | No | 234/1126 | 1.40 (1.07–1.83) | 1.38 (1.06–1.80) | AP: 0.04 (−0.20–0.27) |
| Yes | Yes | 806/2566 | 2.36 (1.91–2.91) | 2.31 (1.88–2.85) | S: 1.07 (0.69–1.64) |
| Ever smoke | History of raw water drinking | ||||
| No | No | 370/1990 | 1.00 | 1.00 | ROR: 1.02 (0.75–1.38) |
| No | Yes | 570/2149 | 1.36 (1.10–1.68) | 1.35 (1.10–1.66) | RERI: 0.19 (−0.24–0.61) |
| Yes | No | 342/1538 | 1.41 (1.09–1.82) | 1.39 (1.08–1.79) | AP: 0.10 (−0.12–0.31) |
| Yes | Yes | 668/2067 | 1.96 (1.55–2.46) | 1.92 (1.53–2.42) | S: 1.24 (0.72–2.14) |
| Ever smoke | Mildew-contaminated food intake | ||||
| No | No | 868/3888 | 1.00 | 1.00 | ROR: 0.91 (0.55–1.50) |
| No | Yes | 84/312 | 1.28 (0.88–1.87) | 1.26 (0.87–1.81) | RERI: −0.05 (−0.78–0.68) |
| Yes | No | 890/3318 | 1.44 (1.20–1.73) | 1.43 (1.19–1.72) | AP: −0.03 (−0.48–0.41) |
| Yes | Yes | 135/334 | 1.67 (1.18–2.36) | 1.62 (1.16–2.27) | S: 0.93 (0.32–2.67) |
| Ever smoke | Family history of liver cancer | ||||
| No | No | 849/4121 | 1.00 | 1.00 | ROR: 1.09 (0.63–1.89) |
| No | Yes | 122/120 | 3.93 (2.58–6.00) | 3.50 (2.34–5.24) | RERI: 1.73 (−0.91–4.37) |
| Yes | No | 886/3563 | 1.42 (1.19–1.69) | 1.41 (1.19–1.68) | AP: 0.28 (−0.07–0.64) |
| Yes | Yes | 154/129 | 6.08 (4.17–8.87) | 5.37 (3.73–7.73) | S: 1.52 (0.81–2.84) |
Adjusted for study area (Dafeng = 1, Ganyu = 2, Chuzhou = 3, Tongshan =4), age (continuous), gender (male = 0, female = 1), education level (illiteracy = 0, primary = 1, middle school = 2, high school and college = 3), marital status (in marriage = 1, single, divorced or widowed = 0), family income 10 years ago per capita (Yuan/year, continuous), BMI (continuous), history of raw water drinking (yes = 1, no = 0), history of mildew-contaminated food intake (yes = 1, no = 0), family history of liver cancer (yes = 1, no = 0), weekly alcohol consumption in 1990s (continuous, mL/week), HBsAg status (positive = 1, negative = 0) and anti-HCV status (positive = 1, negative = 0), except for in the models for each variable itself.