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. Author manuscript; available in PMC: 2018 Aug 7.
Published in final edited form as: Nature. 2018 Feb 7;554(7692):387–391. doi: 10.1038/nature25477

Figure 2. Structure comparison of free and DNA-bound DNMT3A–DNMT3L tetramer.

Figure 2

a, Schematic view of the intermolecular interactions between DNMT3A and DNA. The hydrogen-bonding, electrostatic and van der Waals contacts are represented by red, blue and black arrows, respectively. Water-mediated hydrogen bonds are labeled with letter ‘W’. b, Structural overlay of free (grey) and DNA-bound (cyan) DNMT3A–DNMT3L. The disordered TRD loops in free DNMT3A-DNMT3L are depicted as dotted lines. c, The TRD loop (blue) in DNA-bound DNMT3A is stabilized by hydrogen-bonding interactions (dashed lines) with R882 and Q886. d, Structural overlay of the catalytic loop between free (grey) and DNA-bound (blue) DNMT3A. e, DNA intercalation by DNMT3A V716.