Figure 4. Co-mutations with DNMT3A in acute myeloid leukaemia and other diseases.

a | Mutations in nucleophosmin (NPM1) and internal tandem duplication in the gene encoding the receptor tyrosine kinase FLT3 (FLT3^ITD) occur more frequently in DNA methyltransferase 3A (DNMT3A)-mutant acute myeloid leukaemia (AML) than in non-DNMT3A-mutant AML. Each column represents a patient from The Cancer Genome Atlas (TCGA) database. Each coloured mark represents a mutation (light blue) or deletion (dark blue). The frequency of patients with each mutation is indicated on the left-hand side. The figure was made using cBioPortal^160,161. b | Frequent co-mutations with DNMT3A. AITL, angioimmunoblastic T cell lymphoma; ASXL1, additional sex combs-like transcriptional regulator 1; CDKN, cyclin-dependent kinase inhibitor; IDH, isocitratedehydrogenase; JAK2, Janus kinase 2; KMT2A, histone-lysine N-methyltransferase KMT2A (also known as MLL); MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasm; PHF6, PHD finger protein 6; PTCL, peripheral T cell lymphoma; RHOA, RAS homologue family member A; SF3B1, splicing factor 3b, subunit 1; SRSF2, serine/arginine-rich splicing factor 2; T-ALL, T cell acute lymphoblastic leukaemia; U2AF1, U2 small nuclear RNA auxiliary factor 1.*One large study showed significant association, but another study found no association. ^‡One study found a significant association with IDH2 mutations that was not confirmed in two additional large studies.