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. 2018 Feb 15;8:3085. doi: 10.1038/s41598-018-21551-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protection from ECM and parasitemia in RAS immunized mice after challenge with infected red blood cells (iRBC). (A) A single i.v. RAS immunization (n = 8) protected animals from ECM after challenge with 10⁵ iRBC (***P < 0.001, logrank test). (B) Following a challenge with 10⁵ infected red blood cells, the development of blood stage parasites parasitemia was decelerated in RAS immunized mice resulting in significantly lower parasitemia on days 5 to 7 after challenge in comparison to mock-control mice (*P < 0.05, (**P < 0.01, ***P < 0.001, Mann-Whitney-U-test).