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. 2018 Feb 15;8:3090. doi: 10.1038/s41598-018-21439-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IXR1 deletion affects transcription of other yeast general regulators. (A) Regulatory network showing the role that Ixr1 has, represented in circular or extended layouts of the major transcriptional regulators Tec1 (red), Sok2 (orange), Abf1 (green) and Sfp1 (dark blue). Dark dashed lines indicate direct nodes between general regulators and rhombus correspond to genes that encode transcriptional regulators. Genes related to translation [GO:0006412] are light green, ncRNA metabolism [GO:0034660] pink, transcription [GO:0006351] light blue, transport [GO:0006810] violet, hexose metabolism [GO:0019318] brown, sexual reproduction [GO:0019953] yellow, and others grey. (B) qPCR confirmation of the regulation exerted by Ixr1 on major nodes; analysis of HHO1 expression was included as a non-regulated control. Wt, W303 strain; W/O, without cisplatin treatment.