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. 2018 Feb 15;8:3090. doi: 10.1038/s41598-018-21439-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in Ixr1 binding produced by cisplatin treatment. (A) Venn diagram of statistically significant Ixr1 binding peaks in promoter regions before (blue) and after (red) cisplatin treatment, obtained by ChIP-on-chip experiments. (B) Examples of Ixr1-peaks before (blue) and after (red) cisplatin treatment, obtained by ChIP-on-chip for the genes SNP1, NMD3, UBP10 and RSA4. Y-axis represents signal values after input background subtraction. Bars at the top mark the peaks of interest reported by TAS. (C) Logo representation of de novo consensus sequences derived with HOMER from Ixr1 binding peaks related to promoter regions before and after cisplatin treatment, aligned with known consensus sequences in Jaspar database. (p-value: 1e−12, for motif significance according to HOMER).