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. 2018 Feb 15;8:3090. doi: 10.1038/s41598-018-21439-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Speculative model about how connections of Ixr1 regulation, TOR and PKA signaling influence ribosome biogenesis. (A) Ribosome biogenesis activated by transcriptional regulation mediated by Ixr1 and post-translational modifications dependent on TOR and PKA signaling. (B) Decrease of ribosome biogenesis as anticipated from IXR1 knockout or TOR inactivation. The color in the forms reflects Ixr1 transcriptional regulation, activation (red) or repression (green). The intensity of the color indicates the fold change ixr1∆ versus W303, according to the scale. White letters are used for activation of signal pathways and targets, and black letters for their inactivation.