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. 2018 Feb 15;8:3124. doi: 10.1038/s41598-018-20435-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regional plots for the new risk loci identified in single variant analyses in this study. The most significantly associated SNPs in each region are marked as solid purple diamonds. Pairwise correlations (LD r²) between the top SNP and the other SNPs in a 400 kb flanking region are illustrated by different colours. Blue spikes show estimated recombination rates. (a) rs72815193 on chromosome 10 near MYOF, CYP26A1, and CYP26C (the most significant results were obtained in combined OAG and VCDR analysis conducted in combined Asians and European ancestry). (b) rs56962872 on chromosome 3 within LOC253573 (LINC02052), near CRYGS and TBCCD1 (the most significant results were obtained in combined OAG and VCDR analysis conducted in European ancestry). (c) rs6478746 on chromosome nine near LMX1B (the most significant results were obtained in combined OAG and CA in European ancestry). (d) rs9530458 on chromosome 13 within LMO7 (combined OAG data from ANZRAG and NEIGHBORHOOD). cM = centimorgan.