Table 1.
Kinetic family | Composition | Kinetic pattern | |
---|---|---|---|
Phenotypic family | Cell population | ||
I | Granulocytes 14; 11, 19, and 1 Monocytes-DCs 30 | Neutrophils, including poorly to moderately activated neutrophils and uncharacterized APCs | Post-prime enrichment |
III | Granulocytes 8; 4 and 13; 3 | ||
II | Granulocytes 6 and 2; 7 and 5 Monocytes-DCs 35 and 41 | Neutrophils, including moderately to highly activated neutrophils, highly activated monocytes, CCR5highCXCR4highcDCs, and inflammatory cDCs/non-classical monocytes | Post-boost enrichment |
IV | Granulocytes 9 and 15 | ||
VI | Granulocytes 12 and 16 | ||
X | Monocytes-DCs 24 and 32; 39 and 29 | ||
V | Granulocytes 20; 17 and 10 Monocytes-DC 42 and 25 | Neutrophils, poorly to highly activated monocytes, HLA-DRlowcDCs, and uncharacterized APCs | Post-prime and post-boost enrichment |
VIII | Granulocytes 21 Monocytes-DCs 38, 36 and 22 | ||
IX | Monocytes-DCs 23 and 34; 31; 27 | ||
VII | Granulocytes 18 | Basophils, pDCs, CD14lowmonocytes, and cDCs including HLA-DRlowand CD64highcDCs | No/heterogeneous enrichment |
XI | Monocytes-DCs 28; 37 and 26 | ||
XII | Monocytes-DCs 33 and 40 |
For each kinetic family, its composition in terms of phenotypic families (listed from top to bottom from the corresponding heatmaps (Fig. 4) and separated by “;” to designate their being from different superfamilies) and its main cell populations and phenotypes, as well as its kinetic pattern, as classified in Fig. 5a, are indicated.