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. 2018 Feb 15;8:3104. doi: 10.1038/s41598-018-21468-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bushen-Yizhi Formula improved learning and memory abilities in APP/PS1 mice. (A) Escape latencies in water maze during the positioning navigation test. (B) Representative tracings of animal paths during the positioning navigation test on the 5^th day. (C) Number of times crossing the platform location during the probe trial. (D) Time spent in the target quadrant and in the opposite quadrant during the probe trial. (E) The partial index on the second day during the novel-object recognition test. (F) The partial index on the third day during the novel-object recognition test. Groups included a low-dose of BSYZ (1.46 g/kg/d), a medium-dose of BSYZ (2.92 g/kg/d) and a high-dose of BSYZ (5.84 g/kg/d). Data are shown as the mean ± SD (n = 11 in each group). ^#P < 0.05 and ^##P < 0.01 versus the wild-type group. ^*P < 0.05 and ^**P < 0.01 versus the model group.