Table 3.
Association between maternal genotypes and the risk of CHDs.
| dbSNP_ID | Model | Genotype | Controls | Cases | aOR(95%CI) | P-value | FDR-BH P value |
|---|---|---|---|---|---|---|---|
| N(%) | N(%) | ||||||
| rs2158041 | Dominant | C/C | 168 (62.2) | 194 (54.3) | 1 | 0.03656 | 0.1828 |
| C/T- T/T | 102 (37.8) | 163 (45.7) | 1.454 (1.024, 2.065)* | ||||
| Recessive | C/C- C/T | 253 (93.7) | 331 (92.7) | 1 | 0.6361 | 0.8959 | |
| T/T | 17 (6.3) | 26 (7.3) | 1.179 (0.596, 2.332) | ||||
| Log-additive | — | — | — | 1.303 (0.9841, 1.725) | 0.06457 | 0.2544 | |
| rs7811989 | Dominant | G/G | 169 (62.6) | 194 (54.3) | 1 | 0.03491 | 0.1828 |
| G/A-A/A | 101 (37.4) | 163 (45.7) | 1.46 (1.027, 2.075)* | ||||
| Recessive | G/G-G/A | 252 (93.3) | 331 (92.7) | 1 | 0.7877 | 0.8959 | |
| A/A | 18 (6.7) | 26 (7.3) | 1.097 (0.5606, 2.145) | ||||
| Log-additive | — | — | — | 1.287 (0.9736, 1.702) | 0.07631 | 0.2544 | |
| rs2066853 | Dominant | G/G | 111 (41.1) | 163 (45.7) | 1 | 0.1473 | 0.453 |
| G/A-A/A | 159 (58.9) | 194 (54.3) | 0.7704 (0.5414,1.096) | ||||
| Recessive | G/G-G/A | 237 (87.8) | 326 (91.3) | 1 | 0.0622 | 0.4806 | |
| A/A | 33 (12.2) | 31 (8.7) | 0.5861 (0.3342,1.028) | ||||
| Log-additive | — | — | — | 0.7648 (0.5859,0.9983)* | 0.04855 | 0.2428 | |
| rs2040623 | Dominant | A/A | 96 (35.6) | 141 (39.5) | 1 | 0.1137 | 0.453 |
| A/C-C/C | 174 (64.4) | 216 (60.5) | 0.7453 (0.5178,1.073) | ||||
| Recessive | A/A-A/C | 228 (84.4) | 314 (88.0) | 1 | 0.07209 | 0.4806 | |
| CC | 42 (15.6) | 43 (12.0) | 0.6322 (0.3836,1.042) | ||||
| Log-additive | — | — | — | 0.761 (0.5867,0.9872)* | 0.03969 | 0.2428 | |
| rs1048943 | Dominant | T/T | 146 (54.1) | 194 (54.3) | 1 | 0.9835 | 0.9835 |
| T/C- C/C | 124 (45.9) | 163 (45.7) | 1.004 (0.7102, 1.418) | ||||
| Recessive | T/T- T/C | 254 (94.1) | 330 (92.4) | 1 | 0.3767 | 0.8126 | |
| C/C | 16 (5.9) | 27 (7.6) | 1.375 (0.6786, 2.786) | ||||
| Log-additive | — | — | — | 1.055 (0.7976, 1.395) | 0.708 | 0.885 | |
| rs4646422 | Dominant | C/C | 201 (74.4) | 284 (79.6) | 1 | 0.1585 | 0.453 |
| C/T-T/T | 69 (25.6) | 73 (20.4) | 0.7448 (0.4944, 1.122) | ||||
| Recessive | C/C-C/T | 268 (99.3) | 351 (98.3) | 1 | 0.439 | 0.8126 | |
| T/T | 2 (0.7) | 6 (1.7) | 1.934 (0.364, 10.27) | ||||
| Log-additive | — | — | — | 0.8108 (0.5575, 1.179) | 0.2725 | 0.545 | |
| rs4642421 | Dominant | G/G | 84 (31.1) | 108 (30.3) | 1 | 0.6549 | 0.9835 |
| G/A-A/A | 186 (68.9) | 249 (69.7) | 1.089 (0.7487,1.585) | ||||
| Recessive | G/G-G/A | 225 (83.3) | 290 (81.2) | 1 | 0.546 | 0.8401 | |
| A/A | 45 (16.7) | 67 (18.8) | 1.151 (0.7289,1.818) | ||||
| Log-additive | — | — | — | 1.087 (0.8425,1.402) | 0.5219 | 0.8718 | |
| rs762551 | Dominant | A/A | 119 (44.1) | 187 (52.4) | 1 | 0.01651 | 0.1828 |
| A/C- C/C | 151 (55.9) | 170 (47.6) | 0.6529 (0.4608, 0.9252)* | ||||
| Recessive | A/A- A/C | 235 (87.0) | 328 (91.9) | 1 | 0.0703 | 0.4806 | |
| C/C | 35 (13.0) | 29 (8.1) | 0.5969 (0.3414, 1.044) | ||||
| Log-additive | — | — | — | 0.7062 (0.5444, 0.916)* | 0.008771 | 0.1754 | |
| rs4646425 | Dominant | C/C | 238 (88.1) | 291 (81.5) | 1 | 0.03186 | 0.1828 |
| C/T-T/T | 32 (11.9) | 66 (18.5) | 1.723 (1.048, 2.833)* | ||||
| Recessive | C/C-C/T | 270 (100.0) | 354 (99.2) | 1 | 0.9988 | 0.9988 | |
| T/T | 0 (0.0) | 3 (0.8) | — | ||||
| Log-additive | — | — | — | 1.748 (1.077, 2.839)* | 0.02394 | 0.2394 | |
| rs2472304 | Dominant | G/G | 189 (70.0) | 244 (68.3) | 1 | 0.206 | 0.4578 |
| G/A-A/A | 81 (30.0) | 113 (31.7) | 1.278 (0.874,1.867) | ||||
| Recessive | G/G-G/A | 265 (98.1) | 349 (97.8) | 1 | 0.7375 | 0.8959 | |
| A/A | 5 (1.9) | 8 (2.2) | 1.231 (0.3656,4.143) | ||||
| Log-additive | — | — | — | 1.241 (0.8806,1.748) | 0.2175 | 0.5438 | |
| rs2470890 | Dominant | G/G | 189 (70.0) | 244 (68.3) | 1 | 0.1935 | 0.4578 |
| G/A-A/A | 81 (30.0) | 113 (31.7) | 1.287 (0.88,1.881) | ||||
| Recessive | G/G-G/A | 265 (98.1) | 349 (97.8) | 1 | 0.7375 | 0.8959 | |
| A/A | 5 (1.9) | 8 (2.2) | 1.231 (0.3656,4.143) | ||||
| Log-additive | — | — | — | 1.248 (0.8855,1.758) | 0.2058 | 0.5438 | |
| rs2855658 | Dominant | C/C | 217 (80.4) | 283 (79.3) | 1 | 0.9736 | 0.9835 |
| C/T- T/T | 53 (19.6) | 74 (20.7) | 1.007 (0.6578, 1.542) | ||||
| Recessive | C/C - C/T | 265 (98.1) | 353 (98.9) | 1 | 0.9292 | 0.9781 | |
| T/T | 5 (1.9) | 4 (1.1) | 0.9364 (0.2199, 3.987) | ||||
| Log-additive | — | — | — | 1.001 (0.6818, 1.47) | 0.995 | 0.995 | |
| rs1056837 | Dominant | G/G | 217 (80.4) | 282 (79.0) | 1 | 0.8692 | 0.9835 |
| G/A-A/A | 53 (19.6) | 75 (21.0) | 1.036 (0.6772, 1.586) | ||||
| Recessive | G/G-G/A | 265 (98.1) | 353 (98.9) | 1 | 0.4875 | 0.8126 | |
| A/A | 6 (1.9) | 4 (1.1) | 0.6042 (0.1457, 2.506) | ||||
| Log-additive | — | — | — | 0.9918 (0.6774, 1.452) | 0.9663 | 0.995 | |
| rs1056836 | Dominant | G/G | 216 (80.0) | 280 (78.4) | 1 | 0.8848 | 0.9835 |
| G/C- C/C | 54 (20.0) | 77 (21.6) | 1.032 (0.6764, 1.573) | ||||
| Recessive | G/G - G/C | 264 (97.8) | 353 (98.9) | 1 | 0.4875 | 0.8126 | |
| C/C | 6 (2.2) | 4 (1.1) | 0.6042 (0.1457, 2.506) | ||||
| Log-additive | — | — | — | 0.9887 (0.6769, 1.444) | 0.9532 | 0.995 | |
| rs1056827 | Dominant | C/C | 171 (63.3) | 228 (63.9) | 1 | 0.7812 | 0.9835 |
| C/A- A/A | 99 (36.7) | 129 (36.1) | 1.052 (0.7341, 1.508) | ||||
| Recessive | C/C - C/A | 260 (96.3) | 343 (96.1) | 1 | 0.3418 | 0.8126 | |
| A/A | 10 (3.7) | 14 (3.9) | 1.554 (0.6262, 3.856) | ||||
| Log-additive | — | — | — | 1.092 (0.8036, 1.485) | 0.5729 | 0.8718 | |
| rs10012 | Dominant | G/G | 171 (63.3) | 230 (64.4) | 1 | 0.9318 | 0.9835 |
| G/C-C/C | 99 (36.7) | 127 (35.6) | 1.016 (0.708, 1.458) | ||||
| Recessive | G/G-G/C | 260 (96.3) | 342 (95.8) | 1 | 0.2845 | 0.8126 | |
| C/C | 10 (3.7) | 15 (4.2) | 1.631 (0.6658, 3.995) | ||||
| Log-additive | — | — | — | 1.072 (0.7899, 1.456) | 0.6543 | 0.8724 | |
| rs3813867 | Dominant | G/G | 171 (63.3) | 213 (59.7) | 1 | 0.3651 | 0.6637 |
| G/C- C/C | 99 (36.7) | 144 (40.3) | 1.178 (0.8266, 1.678) | ||||
| Recessive | G/G- G/C | 258 (95.6) | 344 (96.4) | 1 | 0.4491 | 0.8126 | |
| C/C | 12 (4.4) | 13 (3.6) | 0.7175 (0.3037, 1.695) | ||||
| Log-additive | — | — | — | 1.082 (0.7998, 1.463) | 0.6103 | 0.8718 | |
| rs2031920 | Dominant | C/C | 171 (63.3) | 213 (59.7) | 1 | 0.3651 | 0.6637 |
| C/T-T/T | 99 (36.7) | 144 (40.3) | 1.178 (0.8266, 1.678) | ||||
| Recessive | C/C-C/T | 258 (95.6) | 344 (96.4) | 1 | 0.4491 | 0.8126 | |
| T/T | 12 (4.4) | 13 (3.6) | 0.7175 (0.3037, 1.695) | ||||
| Log-additive | — | — | — | 1.082 (0.7998, 1.463) | 0.6103 | 0.8718 | |
| rs915908 | Dominant | G/G | 190 (70.4) | 252 (70.6) | 1 | 0.7128 | 0.9835 |
| G/A-A/A | 80 (29.6) | 105 (29.4) | 1.074 (0.7346, 1.57) | ||||
| Recessive | G/G-G/A | 258 (95.6) | 345 (96.6) | 1 | 0.8063 | 0.8959 | |
| A/A | 12 (4.4) | 12 (3.4) | 0.8921 (0.3581, 2.222) | ||||
| Log-additive | — | — | — | 1.037 (0.7549, 1.424) | 0.8237 | 0.9691 | |
| rs6413432 | Dominant | T/T | 145 (53.7) | 198 (55.5) | 1 | 0.5408 | 0.9014 |
| T/A-A/A | 125 (46.3) | 159 (44.5) | 0.8977 (0.6352, 1.269) | ||||
| Recessive | T/T-T/A | 248 (91.9) | 338 (94.7) | 1 | 0.1336 | 0.6682 | |
| A/A | 22 (8.1) | 19 (5.3) | 0.5923 (0.2988, 1.174) | ||||
| Log-additive | — | — | — | 0.8556 (0.6482, 1.129) | 0.2707 | 0.545 |
aOR: adjusted odds ration, adjusted for maternal age, gestational week, housing renovation, factory or landfill nearby, cooking at home, parental smoking or ETS exposure, maternal alcohol consumption, folic acid supplements.