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. 2017 Oct 17;75(6):1099–1115. doi: 10.1007/s00018-017-2682-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Lk- and DH44-RNAi knockdown efficiency was tested using immunolabelling. a, b Knockdown of Lk with Lk-GAL4driven Lk-RNAi causes a significant decrease in LK-immunoreactivity in the adult brain and ventral nerve cord (VNC). ****p < 0.0001, as assessed by unpaired t test. c Fluorescence intensity measurement of lateral horn LK neurons shows a significant decrease in LK-immunoreactivity in Lk knockdown flies compared to control flies. CTCF corrected total cell fluorescence. d DH44-GAL4-driven Lk-RNAi causes a significant decrease in LK-immunoreactivity in the adult VNC as determined by the number of immunoreactive neurons (the average number of neurons is indicated in each panel; see Figure S6) that could be detected. However, DH44-GAL4-driven DH44-RNAi causes a significant increase in LK-immunoreactivity in adult ABLKs (***p < 0.001, as assessed by unpaired t test). (e) and a complete abolishment of DH44-immunoreactivity in the adult brain (f) and VNC (g)