. 2017 Aug 8;57(3):267–286. doi: 10.1007/s40262-017-0578-5

Table 1.

Pharmacokinetic parameters of micafungin in healthy subjects

Dose (mg)	Subjects		Mean pharmacokinetic parameters (% coefficient of variation) [range]										References
	Subjects		Weight (kg)	C _max (mg/L)	C_max at SS (mg/L)	C_24h, mg/L	C_24h at SS (mg/L)	AUC₂₄ (mg h/L)	AUC (mg h/L)	t _½ (h)	CL (mL/h/kg)	V _d (L/kg)
	n	SD or SS	Weight (kg)	C _max (mg/L)	C_max at SS (mg/L)	C_24h, mg/L	C_24h at SS (mg/L)	AUC₂₄ (mg h/L)	AUC (mg h/L)	t _½ (h)	CL (mL/h/kg)	V _d (L/kg)
100	26 SD		73.7	NR	NR	NR	NR	NR	136.4 (19)^a	16.4 (16)	10.4 (20)	0.215 (13)	[20]
	8 SD		84 (11)	8.8 (20) [5.1–11.3]	NR	NR	NR	NR	125.9 (21) [84.3–160.4]^a	14.6 (21) [11.7–20.4]	9.8 (18) [7.2–13.6]	0.199 (14) [0.167–0.260]	[21]
	9 SD		85 (18)	8.2 (17) [5.7–9.8]	NR	NR	NR	NR	120.9 (14) [102.6–149.4]^a	15.1 (12) [12.4–17.8]	10 (16) [8–13.4]	0.202 (18) [0.168–0.284]	[21]
	27 SD		71.7	NR	NR	NR	NR	NR	133.4 (14)^a	14.8 (9)	10.8 (11)	NR	[19]
	8 SD		70.2 (22)	10.3 (24)	NR	2^b	NR	96.8 (21)	142.4 (20)^a	14.9 (10)	10.4 (20)	0.224 (25)	[24]
Weighted average			75	9.1 (20)					133 (17)	15.4 (13)	10.4 (16)	0.2 (16)
150	23 SS		NR	NR	15.9 (13)	NR	4^b	NR	180.9 (17)	NR	NR	NR	[22]
	16 SS		NR	12 (19)	16 (17)	2.5^b	4^b	116 (19)	182 (19)	NR	NR	NR	[23]
Weighted average					16 (15)		4		181 (18)

NR not reported, C _max maximum plasma concentration, SD single dose, SS steady state, C _24h trough plasma concentration 24 h after dosing, AUC ₂₄ area under the plasma concentration-time curve after a single dose from zero to 24 h, AUC area under the plasma concentration-time curve at steady state from zero to 24 h, or, when indicated, from zero to infinity after a single dose, t _½ terminal half-life, CL clearance, V _d volume of distribution; average is weighted by the number of patients reported

^a AUC_∞ after a single dose

^b Values not reported but extracted from figures with time versus concentration curves