Table 2.

Population pharmacokinetic models for micafungin

Year	Population	Subjects, n	Samples, n	Covariates tested	Compartments, n	Covariates in final model				References
						CL	V central	Q	V peripheral
2009	Preterm neonates	30	NR	NR	2	None	None	None	None	[64]
2016	Preterm neonates	18	72	NR	2	Weight, AST/ALT ratio	Weight	Weight	None	[38]
2010	Preterm neonates and young infants	47	NR	Weight	2	Weight	Weight	None	None	[60]
2015	Pediatric patients (4 months–17 years)	229	1919	Weight, age, age group, sex, albumin, serum creatinine, ALT, AST, total bilirubin, red blood cell count, platelet count	2	Weight, AST, total bilirubin	None	None	None	[58]
2007	Pediatric patients (2–17 years)	72	NR	Weight	2	Weight	Weight	None	None	[59]
2006	Japanese adult and pediatric patients	198	1825	Age, weight, BMI, total protein, albumin, urea nitrogen, total bilirubin, AST, ALT, GGT, LDH, AP, creatinine clearance, red blood cell count, hematocrit, platelet count	2	Weight, platelet count	None	None	None	[52]
2008	Adult patients	62	1128	Weight, height, age, sex, race, dose	2	Weight	None	None	None	[53]
2009	Hematology patients	10	48	NR	2	None	None	None	None	[65]
2010	Lung transplant patients	20	NR	Weight, age, sex, race, height, BAL location, BAL duration	4a	None	None	None	None	[45]
2011	Overweight and obese adults	36	252	Weight, sex, age, comorbidities, medication	2	Weight	None	None	None	[55]
2015	Postsurgical patients with peritonitis	10	NR	Weight, serum creatinine, albumin, total bilirubin, medication (vasopressors or diuretics)	3a	Weight	Albumin	None	None	[47]
2016	ICU patients with burns and patients with intra-abdominal infections	25	NR	Weight, sex, dose, percentage burned, others unspecified	3a	None	None	None	None	[41]
2014	ICU patients receiving CVVH	10	NR	Weight, age, sex, total bilirubin, serum creatinine, urea nitrogen, albumin, presence of vasopressor	2	Weight	None	None	None	[63]
2016	ICU patients	99	436	Weight, age, sex, total protein, AST, ALT, AP, total bilirubin, prothrombin time, albumin, SOFA score, ECMO, hemodialysis	2	Weight, albumin, SOFA score	Weight, albumin	None	Weight, albumin	[61]
2017	ICU patients	20	356	Weight, albumin, CVVH, SOFA score	2	Weight	Weight	Weight	Weight	[62]

NR not reported, CL clearance, V _central volume of distribution of the central compartment, Q intercompartmental clearance, V _peripheral volume of distribution of the peripheral compartment, BMI body mass index, AST aspartate transaminase, ALT alanine transaminase, GGT γ-glutamyltransferase, LDH lactate dehydrogenase, AP alkaline phosphatase, ECMO extracorporeal membrane oxygenation, SOFA Sequential Organ Failure Assessment Score, CVVH continuous venovenous hemofiltration, ICU intensive care unit

^a A two-compartment model to describe the plasma concentration, and additional compartments to describe transport to tissue