Table I.

CNS-Wide Effects on Endogenous Metabolites by Dopamine Receptor Agonists and Antagonists

+ (green): increase; - (red): decrease; +/-, -/0 or +/0 (grey): conflicting results; 0 (grey): no effect. In case multiple studies were identified for the effects of a particular drug class on a particular marker, only the 4 most recent publications were reported. ^aOnly in striatum; ^bOnly observations after intracerebral administration; ^cFew and/or conflicting data; ^dMeasured in the prefrontal cortex

DA dopamine, DOPAC 3,4-dihydroxyphenylacetic acid, HVA homovanillic acid, 3-MT 3-methoxytyramine, NE norepinephrine, E epinephrine, VMA vanillylmandelic acid, GABA gamma-aminobutyric acid, 5-HT serotonin, brain_ECF brain extracellular fluid