Table 2.
Comparison of characteristics between anti-apolipoprotein-A1 (AAA1) IgG-positive samples and AAA1 negative samples
| Characteristic | Anti-apolipoprotein Al seropositive, n = 41 | Anti-apolipoprotein Al seronegative, n = 48 | p value * |
|---|---|---|---|
| HCV RNA log10 (IU/ml), mean ± SD | 2.27 ± 2.67 | 1.93 ± 2.68 | 0.552† |
| Total cholesterol (mmol/l), median | 3.90 (1.10) | 4.70 (1.18) | 0.006 |
| (IQR) LDL-C (mmol/l), median (IQR) | 2.16 (1.55) | 2.32 (1.27) | 0.308‡ |
| Apolipoprotein B (g/l), median (IQR) | 0.79 (0.48) | 0.85 (0.41) | 0.063‡ |
| HDL-C (mmol/l), mean ± SD | 1.25 ± 0.39 | 1.54 ± 0.64 | 0.009 |
| Apolipoprotein A1 (g/l), mean ± SD | 1.40 ± 0.33 | 1.60 ± 0.42 | 0.012 |
| Triglyceride (mmol/l), median (IQR) | 1.30 (0.65) | 1.20 (0.93) | 0.341‡ |
| ApoB/apoA1 ratio, median (IQR) | 0.52 (0.37) | 0.50 (0.35) | 0.557‡ |
| TG/HDL-C ratio, median (IQR) | 1.00 (1.00) | 0.85 (1.00) | 0.105‡ |
| TC/HDL-C ratio, median (IQR) | 3.33 (2.17) | 3.11 (2.96) | 0.873‡ |
| Anti-apoA1 antibodiesa, median (IQR) | 48.00 (14.30) | 21.50 (8.84) | < 0.001 |
ApoB/apoA1, apolipoprotein B/apolipoprotein A1 ratio; HDL-C, high-density lipoprotein cholesterol
Parametric variables shown as the mean ± standard deviation. Non-parametric variables shown as the median and interquartile range
LDL-C low-density lipoprotein cholesterol, IQR interquartile range, OD optical density, SD standard deviation, TC/HDL-C total cholesterol/high-density lipoprotein cholesterol, TG/HDL-C triglyceride/high-density lipoprotein cholesterol
*p values presented are for the variable comparison between AAA1 seropositive samples and AAA1 seronegative samples. p < 0.05 was considered significant
†p value calculated using the parametric t test
‡p value calculated using the non-parametric Kruskal-Wallis test
aThe anti-ApoA-1 antibody positivity cutoff was predefined at 37%, which corresponded to an OD405 nm of 0.6 as previously validated and described (18–20)