Table 1.
Patient intrinsic and extrinsic factors assessed in the population pharmacokinetic analysis
| Covariate | Type | Parameters tested |
|---|---|---|
| Age | Continuous | CL, V 1, V 2, Q |
| Body weight | Continuous | CL, V 1, V 2, Q |
| Body mass index | Continuous | CL, V 1, V 2, Q |
| Body surface area | Continuous | CL, V 1, V 2, Q |
| Sex | Categorical | CL, V 1, V 2, Q |
| Race | Categorical | CL, V 1, V 2, Q |
| Ethnicity | Categorical | CL, V 1, V 2, Q |
| Calculated creatinine clearance | Continuous | CL, V 1, V 2, Q |
| Albumin | Continuous | CL, V 1, V 2, Q |
| Aspartate transaminase | Continuous | CL, V 1, V 2, Q |
| Alanine transaminase | Continuous | CL, V 1, V 2, Q |
| Alkaline phosphatase | Continuous | CL, V 1, V 2, Q |
| Total bilirubin | Continuous | CL, V 1, V 2, Q |
| Absolute dose (mg) | Continuous | CL, V 1, V 2, Q |
| Treatment dose (mg/kg) | Categorical | CL, V 1, V 2, Q |
| Cancer indication | Categorical | CL, V 1, V 2, Q |
| Tumor size (mm) | Continuous | CL, V 1, V 2, Q |
| Chemotherapeutic agent | Categorical | CL, V 1, V 2, Q |
CL clearance, V 1 central volume of distribution, V 2 peripheral volume of distribution, Q intercompartmental clearance