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a Plasma concentrations of ALZ-801 (prodrug) and tramiprosate (active drug) over time after single ascending oral administration of ALZ-801 loose-filled capsules at 100, 172, and 300 mg/kg in healthy volunteers (mean + SD, n = 11–16; Study 1 in Table 1). b Tramiprosate exposure (C max and AUCt) versus dose relationship indicates dose linearity. C max maximum concentration, AUC t area under the concentration–time curve from time zero to time t, SD standard deviation
