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. 2017 Oct 23;57(3):315–333. doi: 10.1007/s40262-017-0608-3
We summarize the phase I bridging program to evaluate the safety, tolerability and pharmacokinetics (PK) of ALZ-801 in healthy volunteers.
ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound.
Oral ALZ-801 represents an advanced and markedly improved clinical candidate for the treatment of Alzheimer’s disease.