Fig. 2.

Simulated Ca²⁺/calmodulin-dependent protein kinase (CaMKII)-dependent regulation of late Na⁺ current (I_Na,L) and ryanodine receptor sarcoplasmic reticulum (SR) Ca²⁺-release channel (RyR2) compared with experimental data. A: experimentally measured (16) and simulated I_Na,L (expressed as ratio of levels in Na_v1.5-S571E to Na_v1.5-S571A). B: experimentally measured (53, 57) and simulated intracellular Ca²⁺ concentration ([Ca²⁺]_i) amplitude [ratio relative to the wild-type (WT) model] in RyR2-S2814D and RyR2-S2814A models. Simulations used Grandi human atrial model (18) with modifications as described in methods.