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. 2017 Aug 25;313(6):H1227–H1239. doi: 10.1152/ajpheart.00185.2017

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Fig. 7. — Role of the Na⁺/Ca²⁺ exchanger in altered Ca²⁺ homeostasis induced by phosphorylation of Na_v1.5 and ryanodine receptor sarcoplasmic reticulum (SR) Ca²⁺-release channel (RyR2). A: Na⁺/Ca²⁺ exchanger current (I_NCX) values over time at steady-state 1-Hz pacing frequency for simulated wild-type (WT), Na_v1.5-S571A (superimposed on WT), and Na_v1.5-S571E models. B: I_NCX values over time at steady-state 1-Hz pacing frequency for simulated WT, RyR2-S2814A (superimposed on WT), and RyR2-S2814D models. C and D: peak forward-mode I_NCX (C) and maximum intracellular Ca²⁺ concentration ([Ca²⁺]_i; D) during action potential from initiation of simulation for WT, Na_v1.5-S571E, and RyR2-S2814D models.