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Sex-based alterations in intracellular Ca2+ regulation between cardiomyocytes isolated from surviving female (F) and male (M) actin (ACTC) E99K mutant mice. The time to 50% decay of Ca2+ transients evoked electrically (left) and by rapid application of caffeine (right) is shown. n = 46 cells from male nontransgenic (NTG) animals, 37 cells from male transgenic (TG) animals, 47 cells from female NTG animals, and 42 cells from female TG animals. *P < 0.05 and **P < 0.01, ANOVA.
