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Chronic A61603 treatment improved contraction and reduced cardiomyocyte necrosis. Shown is a summary of averaged data for right ventricular (RV) fractional shortening (FS; black circles) and maximum myofilament force (Fmax; gray triangles) relative to the serum level of cardiac troponin I (cTnI; from data shown in Figs. 1–3). Bleomycin (Bleo) increased cTnI and caused proportional reductions in both RV FS and Fmax. These changes were attenuated by concurrent treatment with A61603.
