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Chronic A61603 treatment reduced reactive oxygen species (ROS)-dependent dihydroethidium (DHE) fluorescence. A: representative images of DHE fluorescence from frozen sections of right ventricular myocardium. DHE fluorescence was low in nonfailing hearts and markedly increased in the bleomycin (Bleo) model. This increase was prevented with concurrent treatment with A61603. B: pooled data. *P < 0.05; **P < 0.01.
