Table 2.

Effect of tracheal instillation of bleomycin or saline on body weight and RV weight

	Number of Test Animals	Body Weight, g	RV Weight, mg	RV Weight/Body Weight, mg/g
Saline	9	27.6 ± 1	28.4 ± 1.3	1.03 ± 0.04
Bleomycin	12	20.2 ± 0.5§	23.6 ± 0.6†	1.18 ± 0.04*
Bleomycin + A61603	10	20.8 ± 0.3§	22.4 ± 1‡	1.08 ± 0.03

Values are presented as means ± SE. A single instillation of bleomycin (0.075 units) or saline was given. After 2 wk, bleomycin resulted in decreases in body weight and right ventricular (RV) free wall weight. RV weight relative to body weight was increased by bleomycin. Significant differences compared with saline are shown:

^*P < 0.05,

^†P < 0.01,

^‡P < 0.001, and

^§P < 0.0001.