Table 1, continued
Authors sample size
NP status	Methodological quality of studies	Intervention $+$ Co intervention	Comparison group $+$ co intervention	Outcomes measures of interest	Clinical relevance status on timing outcomes: between groups $P$ value and effect sizes
Bronfort et al.  and Leininger et al.
$n=$ 272
ASNP	Level A
9/11
No for patient and care provider blinded	IG: MT3 Cx-Tx-STT
Number of sessions decided by therapist over 12 weeks	CG1: UMC
(anti-inflam, acetaminophen/ narcotic; Muscle relaxants)
CG2: Home Exercise $+$ advice
6 to 8 sessions per day	Pain (NPRS)
Functional disabilities (NDI)
Satisfaction with care (information, general care)
(CROM)
Quality of life (SF-36)	IG vs CG1: Yes: At 12 and 52 weeks ($p<$ 0.005; SMD $=$ 0.6–0.5)
Yes: At 8 and 26 weeks ($p<$ 0.05; SMD $=$ 0.5–0.4)
Yes: At 12 and 52 weeks ($p<$ 0.005; MD $=$ 11.6–16.4)
No
No
IG vs CG2: No difference on all outcome measures
Masaracchio et al.
$n=$ 64
ASNP	Level A
9/11
No for patient and care provider blinded	IG: MT3 (MT1 Tx $+$ MT2 Cx) $+$ Exercise
2 times/1 week for all groups	CG : MT2 Cx $+$ Exercises	Pain (NPRS)
Functional disabilities (NDI)	Yes: At 1 week ($p<$ 0,001; SMD $=$ 1.0) Yes: At 1 week ($p<$ 0.001; SMD $=$ 1.1)
Ganesh et al.
$n=$ 80
ASNP	Level B
7/11
No for patient and care provider blinded, ITT and dropouts ($>$ 20%)	IG: MT2 Cx (PAIVMS) $+$ Exercise
5 times/week for 2 weeks and for all groups	CG1: MT4 Cx (SNAGs) $+$ Exercise
CG2: Exercise alone	Pain (VAS)
Disability (NDI)
(CROM)	No
No

ANP: acute neck pain/SNP: subacute neck pain/ASNP: acute-subacute neck pain/VAS: Visual Analogue Scale/NDI: Neck Disability Index/CROM: Active Cervical Range of Motion/PPT: Pressure Pain Threshold/US: ultrasound/NPRS: Numeric Pain Rating Scale/FABQ: Fear-Avoidance-Belief-Questionnaire/SF-36: Short-form-health-survey/NPQ: Northwick Pain Questionnaire/UMC: Usual Medical Care/Cx: cervical/Th: thoracic/MOB: Mobilization/SNAGs: Sustained Natural Apophyseal Glides/HVLA: high velocity low amplitude thrust/IG: Intervention Group/CG: Control Group/IRT: Infrared Radiation Therapy/PAIVMS: Passive Accessory Intervertebral Movements/STT: Soft-Tissues-Techniques/SUS: Sham Ultrasound/Yes: significant difference with moderate to large clinical effect size/No: no significant difference with small clinical effect size on all timing outcome measures.