Table 2.

Summary of articles for patients with chronic neck pain

Authors Sample size
NP status	Methodological quality of studies	Intervention $+$ Co intervention	Comparison group $+$ co intervention	Outcomes measures of interest	Clinical relevance status on timing outcomes: between groups $P$ value and effect sizes
Izquierdo-Pérez et al.
$n=$ 61
CNP	Level A
9/11
care provider not blind and dropouts ($>$ 20%)	IG: MT1 Cx
4 sessions over 2 weeks	CG1: MT2 Cx (PAIVMS)
CG2: MT4 Cx (SNAGs)
4 sessions over 2 weeks	PAIN (VAS) Functional disabilities (NDI)
(CROM)
-Ext	NO
NO
: YES: immediately after treatment up to 3 months ($p<$ 0.01; SMD $⩾$ 0.5)
Lopez et al.
$n=$ 48
CNP	Level A
9/11
Care provider not blind
Difference at baseline: CROM in Flexion/Extension	IG: MT1 Cx
1 single session	CG1: MT2 Cx (PAIVMS)
CG2: MT4 Cx (SNAGs)
1 session	PAIN
(VAS)
(PPT)
Functional disabilities (CROM)	IG and CG1 vs CG2: YES: immediately after treatment only for pain at rest ($p=$ 0.04) with SMD $=$ 0.5–1.1)
NO
NO
NO
Saavedra-Hernandez et al.
$n=$ 80
CNP	Level A
9/11
No for patient and care provider blinded	IG: MT1 on Cx-Tx
(1 sessions: 2 Cx-thrusts)	CG: Kinesio Taping
(wearing during 1 week)	-Pain (NPRS)
-Functional disabilities (NDI)
(CROM)
-flex, ext, latflex
-Right rot
-Left rotation	NO
NO
NO
IG vs CG: YES: at 7 days ($p<$ 0.01; SMD $=$ 0.6; MD $=$ 6.8)
IG vs CG: YES: at 7 days ($p<$ 0.01; SMD $=$ 0.6; MD $=$ 7.0)
Martinez-Segura et al.
$n=$ 90
CNP	Level A
9/11
No for patient and care provider not blind	IG: MT1 on Cx (left) MT1 on Cx (right)	CG: MT1 on Tx	Pain (PPT) Functional disabilities (CROM)	NO
NO
Sherman et al.
$n=$ 64
CNP	Level A
9/11
No for patient and care provider blinded	IG : MT2 (STT)
10 times over 10 weeks	CG: no treatment:self-care-book	Pain (NPRS)
Functional disabilities (NDI) Overall improvement (SF-36)	YES: at 4 weeks, ($p=$ 0,006; MD $=$ 1,6)
YES: at 4 weeks, ($p=$ 0.047; MD $=$ 2.1)
NO
Schwerla et al.
$n=$ 41
CNP	Level A
9/11
No for care provider blinded and ITT	IG: MT3 Cx-Tx $+$ SUS
9 times every 12 to 20 days	CG: no- treatment: SUS 9 times every 4 to 10 days	Pain (NPRS)
-Average pain
-Actual pain
-Worst pain
Functional disabilities (NPQ)
Overall improvement (SF-36)	YES: At 1 week ($p=$ 0.02; SMD $=$ 0.9; MD $=$ 1.7)
at 3 months ($p=$ 0.009; MD $=$ 1.5)
at 3 months ($p=$ 0.03; MD $=$ 1.6)
at 3 months ($p=$ 0.05; MD $=$ 1.2)
YES: at 3 months ($p=$ 0.01; MD $=$ 9)
YES: at the end of treatment ($p=$ 0.02; MD $=$ 13.3)
Lau et al.
$n=$ 120
CNP	Level A
9/11
No for patient and care provider blinded	IG : MT1 Tx $+$ IRT and exercise
8 times (/weeks) for all groups $+$ home exercises	CG: IRT $+$ exercise	Pain (NPRS)
Functional disabilities (NPQ)
(CROM)
-Ext
-Flex
-L Lat Flex
-R Lat Flex
Overall improvement (SF-36)	YES: at post treatment, at 3 months, and at 6 months ($p<$ 0.05; SMD $>$ 0.6)
YES: at post treatment and at 3 months ($p<$ 0.02 SMD $=$ 0.5), at 6 months, ($p=$ 0.007, SMD $=$ 0.4)
YES: at 3 months ($p=$ 0.001; SMD $=$ 0.8) at 6 months ($p=$ 0.001, SMD $=$ 0.5; MD $=$ 3.8)
YES: at post treatment, at 3 months and at 6 months ($p<$ 0.05; SMD $>$ 0.5)
YES: at 3 months and at 6 months ($p<$ 0.005; SMD $>$ 0.5)
YES: at 3 months and at 6 months ($p<$ 0.05; SMD $⩾$ 0.6)
YES: at post treatment, at 3 months and at 6 months ($p⩽$ 0.002; SMD $>$ 0.60)