Fig. 2.

The interaction of affective symptoms by theCOMThaplotype. Abbreviations: PSE, a short version of the Present State Examination; PSF, the Psychiatric Symptom Frequency scale; GHQ-28, the 28-item version of the General Health Questionnaire. Only significant relationships and interactions are shown with standardized coefficients (*p < .05, **p < .01, ***p < .001). The trajectory of affective symptoms and the interactions between adolescent emotional problems and the COMT functional haplotype (red arrow) are shown for men and women. The interaction between adolescent emotional problems and adult affective symptoms at age 53 years by the haplotype in women was indicated under an additive curvilinear model (Haplotype: β = .25, p = .036; haplotype²: β = −.27, p = .026). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)