Table 1.
Demographic characteristics and genotypes in this study.
| Total (n = 2093) | Male (n = 1045) | Female (n = 1048) | Gender differences P value3) | |
|---|---|---|---|---|
| Affective symptoms, mean [SD] | ||||
| Adolescents emotional problem1) | −0.06 [0.97] | −0.15 [0.95] | 0.02 [0.98] | < .001 |
| PSE index of definition score at age 36 years | 1.9 [1.2] | 1.7 [1.1] | 2.1 [1.3] | < .001 |
| PSF total score at age 43 years | 10.4 [10.1] | 8.7 [8.7] | 12.1 [11.1] | < .001 |
| GHQ-28 score at age 53 years | 2.5 [4.4] | 1.9 [3.8] | 3.1 [4.9] | < .001 |
| GHQ-28 score at age 60–64 years | 2.3 [3.7] | 1.7 [3.0] | 2.8 [4.3] | < .001 |
| COMT functional haplotype2), n (%) | ||||
| Highest (valA/valA) | 355 (17.1) | 183 (17.7) | 172 (16.5) | .94 |
| Second highest (valA/met) | 861 (41.5) | 432 (41.7) | 429 (41.3) | |
| Middle (valA/valB or met/met) | 664 (32.0) | 326 (31.5) | 338 (32.5) | |
| Second lowest (valB/met) | 182 (8.8) | 88 (8.5) | 94 (9.0) | |
| Lowest (valB/valB) | 14 (0.7) | 7 (0.7) | 7 (0.7) |
Abbreviations: PSE, the Present State Examination; PSF, the Psychiatric Symptom Frequency; GHQ-28, the 28 item version of the General Health Questionnaire.
1) Z scores.
2) The functional haplotype was defined by three SNPs (rs6269, rs4818, and rs4680), and each participant was categorized into five in accordance with dopamine availability.
3) Gender differences were tested using t-test. Bold shows 5% level significance.