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Effect of nitic oxide (NO) synthase inhibition with l-NMMA on passive leg movement (PLM)-induced hyperemia in young, healthy individuals. These data from Trinity et al. (71) indicate that NO is responsible for up to 80% of the overall PLM-induced hyperemic response. Other studies have verified this observation, supporting the role of NO in the PLM response (24, 45, 70). Note that passive leg movement begins at 0 s. AUC, area under the curve. *Significantly different from control.
