Table 1.
Exercise |
||||||
---|---|---|---|---|---|---|
10% MVC | 20% MVC | 30% MVC | Recovery | Ischemia | Reperfusion | |
NMR measurements | ||||||
deoxyMb, % | 6* | 23 ± 7 | 40 ± 9 | NM | 100 | NM |
Po2, mmHg | 45.90* | 9.81 | 4.40 | NM | ND | NM |
ΔPCr, % | 11 ± 4 | 20 ± 7 | 34 ± 10 | NM | 7 ± 2 | NM |
ΔpH | 0.02 ± 0.02 | 0.08 ± 0.06 | 0.21 ± 0.14 | NM | 0.05 ± 0.05 | NM |
VPCr, mM/min | NM | NM | NM | 15.6 ± 3.5 | NM | NM |
kPCr, min−1 | NM | NM | NM | 1.16 ± 0.19 | NM | NM |
t1/2 PCr, min | NM | NM | NM | 0.27 ± 0.04 | NM | NM |
t1/2 DMb, min | NM | NM | NM | NM | 2.2 ± 0.8 | 0.9 ± 0.2 |
NIRS measurements | ||||||
deoxyMb-Hb, % | 19 ± 10 | 33 ± 18 | 47 ± 32 | NM | 100 | NM |
Po2, mmHg | 12.5 | 5.95 | 3.3 | NM | NM | NM |
t1/2 DMb-DHb, min | 0.7 ± 0.2 | 0.5 ± 0.3 | 0.4 ± 0.3 | 0.4 ± 0.2 | 1.4 ± 0.3 | 0.2 ± 0.0 |
Values are expressed as means ± SD. DMb and DMb-Hb signals are normalized to the signal at end of ischemia as 100%. ΔPCr and ΔpH, change relative to resting value. VPCr and kPCr, initial rate and the rate constant of PCr resynthesis, respectively; t1/2 PCr, t1/2 DMb, and t1/2 DMb-DHb, half-time of PCr, deoxyMb, and deoxyMb-Hb kinetics, respectively. Po2 calculation used a P50 of 2.93 mmHg. NM, not measurable; ND, not defined.
DMb signal was not detectable in all subjects.