Fig. 3.

Distinct modulations of pathways are observed between male and female neonatal mice exposed to hyperoxia by gene set enrichment analysis (GSEA) on PND7. Biological processes enriched in the pulmonary transcriptome of hyperoxia-exposed male and female neonatal mice were identified using GSEA. The normalized enrichment score is reported for select enriched pathways (fdr-adjusted q value <0.25). A: top upregulated pathways in both male and female neonatal mice exposed to hyperoxia. B: top downregulated pathways in both male and female neonatal mice. C: pathways that were regulated in opposite directions in male and female mice. PI3K, phosphatidylinositol 3-kinase.