Fig. 4.

Sexually dimorphic modulation of pathways is observed between male and female neonatal mice exposed to hyperoxia by gene set enrichment analysis (GSEA) on PND21. Biological processes enriched in the pulmonary transcriptome of hyperoxia-exposed male and female neonatal mice were identified using GSEA. The normalized enrichment score is reported for select enriched pathways (fdr-adjusted q value <0.25). A: top upregulated pathways in male neonatal mice exposed to hyperoxia on PND21. The graph also shows the direction of enrichment in similarly exposed female mice. B: top upregulated pathways in female mice on PND21 and the direction of enrichment in similarly exposed male mice.