Table 5.
Frequencies of microsatellite phenotype, mutations, and DNA methylation status in each subgroup
| Subgroup 1 | Subgroup 2 | Subgroup 3 | P‐value | |
|---|---|---|---|---|
| 5‐a | ||||
| Microsatellite phenotype | ||||
| Total | 59 (%) | 17 (%) | 30 (%) | |
| High | 14 (23.7) | 1 (5.8) | 0 (0) | <0.001 |
| Low | 5 (8.5) | 0 (0) | 0 (0) | |
| Negative | 40 (67.8) | 16 (94.2) | 30 (100) | |
| 5‐b | ||||
| Mutated gene | ||||
| Total | 59 (%) | 17 (%) | 30 (%) | |
| TP53 positive | 22 (37.3) | 6 (35.3) | 14 (46.7) | NS |
| KRAS positive | 21 (35.6) | 8 (47.1) | 20 (66.7) | 0.02 |
| BRAF positive | 10 (16.9) | 1 (5.8) | 1 (3.3) | NS |
| PIK3CA positive | 5 (8.5) | 0 (0) | 4 (13.3) | NS |
| 5‐c | ||||
| Methylation status | ||||
| Total | 59 (%) | 17 (%) | 30 (%) | |
| HME | 10 (17.0) | 1 (5.8) | 2 (6.6) | NS |
| IME | 30 (50.8) | 8 (47.1) | 17 (56.7) | |
| LME | 19 (32.2) | 8 (47.1) | 11 (36.7) | |
HME, high methylation phenotype; IME, intermediate methylation phenotype; LME, low methylation phenotype.