Table 2. Top breast cancer pairs sorted by the most pronounced Δρ (P < 10−5).
| miRNA | KEGG ID | KEGG name | Δρ | ρ T | ρ N | size | targets | p.DIANA |
|---|---|---|---|---|---|---|---|---|
| hsa-mir-146b | 00330 | Arginine and proline metabolism | 1.15 | 0.44 | −0.71 | 49 (54) | 1 (1) | 0.933 |
| hsa-mir-146b | 05110 | Vibrio cholerae infection | 1.12 | 0.44 | −0.68 | 51 (54) | 0 (0) | 0.933 |
| hsa-mir-146b | 05217 | Basal cell carcinoma | 1.11 | 0.45 | −0.66 | 53 (55) | 1 (1) | 0.933 |
| hsa-mir-146b | 05200 | Pathways in cancer | −1.10 | −0.49 | 0.61 | 316 (326) | 10 (10) | 0.933 |
| hsa-mir-135b | 00980 | Metabolism of xenobiotics by cytochrome P450 | 1.10 | 0.48 | −0.63 | 49 (71) | 0 (0) | 0.685 |
| hsa-mir-146b | 05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.10 | 0.47 | −0.63 | 66 (68) | 0 (0) | 0.962 |
| hsa-mir-135b | 05217 | Basal cell carcinoma | 1.08 | 0.48 | −0.60 | 53 (55) | 5 (5) | 0.517 |
| hsa-mir-146b | 00980 | Metabolism of xenobiotics by cytochrome P450 | 1.08 | 0.46 | −0.61 | 49 (71) | 0 (0) | 1.52e−04 |
| hsa-mir-99a | 00590 | Arachidonic acid metabolism | 1.07 | 0.49 | −0.58 | 48 (59) | 0 (0) | NT |
| hsa-mir-135b | 00520 | Amino sugar and nucleotide sugar metabolism | 1.07 | 0.44 | −0.63 | 47 (48) | 0 (0) | NT |
| hsa-mir-1307 | 00830 | Retinol metabolism | −1.07 | −0.51 | 0.56 | 42 (64) | 0 (0) | NT |
| hsa-mir-1307 | 04976 | Bile secretion | −1.06 | −0.61 | 0.45 | 56 (71) | 0 (0) | 0.046 |
| hsa-mir-135b | 00051 | Fructose and mannose metabolism | 1.06 | 0.44 | −0.63 | 35 (36) | 1 (1) | NT |
| hsa-mir-135b | 05120 | Epithelial cell signaling in helicobacter pylori infection | 1.06 | 0.41 | −0.65 | 66 (68) | 4 (4) | NT |
| hsa-mir-224 | 01040 | Biosynthesis of unsaturated fatty acids | 1.06 | 0.40 | −0.65 | 19 (21) | 0 (0) | NT |
ρ T and ρN are the within-tissue Spearman’s rank correlation for tumor tissue and normal tissue, respectively. A total of 671 tumor samples and 87 normal samples were used to compute correlations. Size denotes the number of genes in the pathway that have been used in the computation of the the PAS. Targets denotes the number of predicted targets of the miRNA on those genes using TargetScan (47). In parenthesis, the total number of genes and targets of the miRNA on the pathway are shown. p.DIANA denotes the miRNA-pathway enrichment P-value as calculated by DIANA mirPath v.3 (48) using TargetScan. NT = no targets found by DIANA on the pathway.