Table 3.
Grade 3 or Higher Adverse Events by Decreasing Incidence (at Least 10% of Total)
| No. of Subjects (%) | ||||||
|---|---|---|---|---|---|---|
| 5‐d Regimens | ||||||
| Adverse Event | 60 mg/m2 (n = 24) | 90 mg/m2 (n = 26) | Total (n = 50) | 10‐d Regimen at 60 mg/m2 (n = 53) | Total (n = 103) | P a |
| Any event | 20 (83) | 25 (96) | 45 (90) | 50 (94) | 95 (92) | |
| Febrile neutropenia | 10 (42) | 17 (65) | 27 (54) | 35 (66) | 62 (60) | .2296 |
| Pneumonia | 4 (17) | 9 (35) | 13 (26) | 24 (45) | 37 (36) | .0669 |
| Thrombocytopenia | 5 (21) | 5 (19) | 10 (20) | 27 (51) | 37 (36) | .0019 |
| Anemia | 5 (21) | 4 (15) | 9 (18) | 23 (43) | 32 (31) | .0123 |
| Neutropenia | 2 (8) | 3 (12) | 5 (10) | 15 (28) | 20 (19) | .0248 |
| Sepsis | 3 (13) | 2 (8) | 5 (10) | 11 (21) | 16 (16) | .176 |
| Hypokalemia | 5 (21) | 3 (12) | 8 (16) | 6 (11) | 14 (14) | >.5 |
| Bacteremia | 3 (13) | 3 (12) | 6 (12) | 6 (11) | 12 (12) | |
| Cellulitis | 4 (17) | 0 | 4 (8) | 6 (11) | 10 (10) | |
| Leukopenia | 3 (13) | 3 (12) | 6 (12) | 4 (8) | 10 (10) | |
Abbreviation: d, day.
a
Comparing the 5‐day regimens (total) and the 10‐day regimen.