Table 1.
Literature review on predictivity of urinary NGAL and plasma NGAL on delayed graft function in renal transplant recipients
| Marker | Number of patients | Cut‐off level | Sensitivity (%) | Specificity (%) | Author (Ref.) |
|---|---|---|---|---|---|
| uNGAL | 176 KTR | 560 ng/mL (day 1) | 68 | 73 | Hollmen 39 |
| uNGAL | 124 KTR | 97 ng/mL (day 1) | 71.8 | 100 | Lacquaniti 42 |
| 105 ng/mL (day 1) | 95.8 | 91.9 | |||
| uNGAL | 123 KTR | 521.7 ng/mL (4 h) | 80 | 68.7 | Cui 43 |
| 559.2 ng/mL (12 h) | 80 | 68.7 | |||
| 688.3 ng/mL (24 h) | 70 | 93.7 | |||
| 295.2 ng/mL (48 h) | 80 | 96.9 | |||
| 297.4 ng/mL (72 h) | 80 | 100 | |||
| uNGAL | 91 KTR | 45 ng/mL (day 1) | 97 | 26 | Hall 36 |
| 350 ng/mL (day 1) | 77 | 74 | |||
| 800 ng/mL (day 1) | 65 | 94 | |||
| uNGAL | 79 KTR | >120 ng/mL (48 h) | 75 | 71 | Nieto‐Ríos 44 |
| uNGAL | 71 KTR | >33.1 μg/mmol sCr (24 h) | 68 | 93 | Pajek 45 |
| uNGAL | 69 KTR | 188.4 ng/mL (day 2) | 64 | 8 | Choi 46 |
| uNGAL | 53 KTR (23 living donor, 30 deceased donor) | 1000 ng/mg sCr (day 0) | 90 | 83 | Parikh 38 |
| uNGAL | 40 KTR | 479 ng/mL (3–6 h) | 77 | 88 | Fonseca 34 |
| 286 ng/mL (8–12 h) | 100 | 76 | |||
| 277 ng/mL (day 2) | 93 | 90 | |||
| 232 ng/mL (day 4) | 93 | 95 | |||
| 63 ng/mL (day 7) | 94 | 84 | |||
| uNGAL | 38 KTR | 128 ng/mL (day 1) | 85.7 | 61.5 | Kanter 47 |
| 124 ng/mL (day 3) | 80 | 83 | |||
| pNGAL | 176 KTR | 423 ng/mL (day 1) | 87 | 77 | Hollmen 48 |
| pNGAL | 67 KTR (39 living related, 1 brain dead, 27 postcardiac death donors) | 500 ng/ml (day 1) | 91 | 97 | Kusaka 49 |
| 350 ng/ml (day 2) | 86 | 90 | |||
| 300 ng/ml (day 3) | 91 | 93 | |||
| pNGAL | 59 KTR | 233.3 ng/mL (day 1) | 76.6 | 77.8 | Lee 50 |
| pNGAL | 50 KTR patients from ECD | 532 ng/mL (day 1) | 90.9 | 80.6 | Cantaluppi 41 |
| pNGAL | 41 KTR | >400 ng/mL (12 h) | 93.3 | 88.5 | Bataille 51 |
| pNGAL | 37 KTR | 309 ng/mL (12 h) | 100 | 92 | Pezeshgi 40 |
| pNGAL | 27 KTR | 174 ng/mL (day 1) | 100 | 95.5 | Rahimzadeh 52 |
For each study, the optimal cut off levels achieving the best combination of sensitivity and specificity are reported.
ECD, extended criteria donors; KTR, kidney transplant recipients; pNGAL, plasma NGAL; sCr, serum creatinine; uNGAL, urinary NGAL.