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The effects of aminoglycosides on the dissociation-mean-time of GTPase-deficient cognate ternary complex. Time traces of dipeptide formation mirrow slow dissociation of GTPase deficient T3 (EF-Tu(H84A)·GTP·Phe-tRNAPhe), pre-bound to the A site of mRNA programmed ribosomes. The chase of GTPase deficient cognate T3 by native cognate T3 was conducted in the absence of aminoglycoside or in the presence of paromomycin, gentamicin or neomycin (see Materials and Methods for details).
