Table 1. Dissociation time, , of the GTPase deficient cognate ternary complex and effective selectivity, , for different near-cognate codons with and without drugs.
No drug | Paromomycin | Gentamicin | Neomycin | |
---|---|---|---|---|
Dissociation time, (s) | 2±0.1 | 26±1 | 130±4 | 320±15 |
Fold increase by drug | 13±1 | 65±4 | 160±11 | |
-value on CUC | 1760±180 | 75 ± 10 | 17 ± 4 | 3.9 ± 0.6 |
Fold decrease by drug | 23± 4 | 104± 27 | 451±84 | |
-value on UCC | 5900±970 | 420 ± 76 | 103 ± 20 | 30 ± 5 |
Fold decrease by drug | 14± 4 | 57± 15 | 197± 46 | |
-value on UUA | 1200±190 | 111 ± 22 | 14.6 ± 0.8 | 9 ± 1.7 |
Fold decrease by drug | 11± 3 | 82± 14 | 133± 33 |