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. 2017 Jun 10;44(2):419–431. doi: 10.1093/schbul/sbx067

Fig. 4.

Fig. 4.

Functional disconnectivity in the SN-related striato-thalamo-cortical network and its clinical correlation in SCZ. Left side of the figure. The violin plots show the significant differences in mean FC in HC and SCZ separately, as well as the significant differences between the 2 groups, at the various relay stations of the SN-related striato-thalamo-cortical network in SFB. The SCZ group showed reduced positive FC between the SN and striatum as well as between the striatum and thalamus, when compared to highly positive FC in HC; by contrast, the SCZ group showed abnormal positive coupling between the thalamus and sensorimotor cortical areas, when compared to no FC in HC. ###P < .001 (1-sample t tests against zero); ***P < .001 (2-sample t tests). Right side of the figure. The scatter plots show in SCZ the partial correlation analysis (with age, gender and movement as covariates) between FC alterations at the various relay stations of the SN-related network in SFB and PANSS total score. A significant correlation between thalamo-sensorimotor FC alterations and psychopathological severity score was detected in SCZ. **P < .01 (correlation analysis). Abbreviations: FC, functional connectivity; SN, Substantia Nigra; St, striatum; Thal, Thalamus; SM Areas, SensoriMotor Areas; SCZ, schizophrenia; HC, healthy controls; SFB, Standard Frequency Band (0.01–0.08 Hz); PANSS, positive and negative syndrome scale.