Figure 3.

Intrinsic excitability and firing properties of the ventral CA1 neurons are distinct from those in the dorsal and intermediate domains. (a) Patch‐clamp recordings from the single cells revealed that ventral CA1 neurons require stronger afferent stimulation to elicit action potential firing. It is supported with significantly more depolarized threshold for the action potential induction in the ventral pyramidal cells compared with the dorso‐intermediate ones (b). (c) Additionally, ventral CA1 pyramidal neurons show significantly deeper after hyperpolarization (AHP) as opposed to the other two domains. (d) Application of depolarizing currents (from 50 to 400 pA) revealed a difference in spike frequency patterns, where the firing rate of ventral CA1 neurons was significantly lower in comparison to both, dorsal and intermediate ones. Current clamp recordings of repetitive firing evoked by current injections (100, 200, 300, and 400 pA) to hippocampal CA1 neurons are shown on the right. Error bars indicate SEM. */#p < .05, where * indicates significant difference between ventral and intermediate slice groups and # indicates significant difference between ventral and dorsal slice groups. Scale bars: 10 mV, 100 ms