Table 2.
Differential Protein Expression in Psychotic Disorder
| Gene Names | Protein Names | Protein ID | P Value | FC in PD | FDR |
|---|---|---|---|---|---|
| A2M | Alpha-2-macroglobulin | P01023 | 2.35E-05 | −1.36 | 0.002452739084173 |
| TNXB | Tenascin-X | P22105 | 6.78E-05 | 1.60 | 0.003010022721392 |
| IGHM | Ig mu chain C region | P01871 | 8.93E-05 | −1.49 | 0.003100233074614 |
| CLEC3B | Tetranectin | P05452 | 0.000238536918096 | 1.21 | 0.005527149972427 |
| BCHE | Cholinesterase | P06276 | 0.00028867379359 | 1.22 | 0.006016201946107 |
| GSN | Gelsolin | P06396 | 0.001184331262904 | 1.13 | 0.013741065106703 |
| ECM1 | Extracellular matrix protein 1 | Q16610 | 0.00156813706243 | 1.23 | 0.015289744574204 |
| IGF2 | Insulin-like growth factor II | P01344 | 0.00185038627232 | 1.26 | 0.016146280605035 |
| C4BPB | C4b-binding protein beta chain | P20851 | 0.001968111624603 | −1.31 | 0.016452583474952 |
| CTBS | Di-N-acetylchitobiase | Q01459 | 0.002116574187167 | 1.23 | 0.016804037125592 |
| SERPINA7 | Thyroxine-binding globulin | P05543 | 0.002123057983554 | 1.17 | 0.016818582457348 |
| VCAM1 | Vascular cell adhesion protein 1 | P19320 | 0.002249659902707 | 1.34 | 0.01709034422445 |
| LUM | Lumican | P51884 | 0.002278966387226 | 1.19 | 0.017150104571853 |
| GPLD1 | Phosphatidylinositol-glycan- specific phospholipase D | P80108 | 0.00234614616507 | 1.42 | 0.017282940815611 |
| HABP2 | Hyaluronan-binding protein 2 | Q14520 | 0.002538350481953 | 1.17 | 0.017633778389896 |
| IGHG3 | Ig gamma-3 chain C region | P01860 | 0.002874794375478 | −1.27 | 0.018546283526309 |
| SEPP1 | Selenoprotein P | P49908 | 0.003146451379488 | 1.21 | 0.019193243065463 |
| CFH | Complement factor H | P08603 | 0.003414262231026 | 1.13 | 0.019765573474774 |
| SERPINF1 | Pigment epithelium-derived factor | P36955 | 0.003757243579115 | 1.13 | 0.02047865413338 |
| F5 | Coagulation factor V | Q28107 | 0.004067608434137 | 1.27 | 0.021055629451341 |
| F9 | Coagulation factor IX | P00740 | 0.004334224194447 | 1.13 | 0.021506865940923 |
| IGFBP3 | Insulin-like growth factor- binding protein 3 | P17936 | 0.007644758410206 | 1.17 | 0.032388279082007 |
| F12 | Coagulation factor XII | P00748 | 0.007824122898499 | 1.19 | 0.032887687197417 |
| CFD | Complement factor D | P00746 | 0.008444673418423 | 1.35 | 0.034556546176356 |
| CFI | Complement factor I | P05156 | 0.010003939954609 | 1.12 | 0.038384336560269 |
| LAMP2 | Lysosome-associated membrane glycoprotein 2 | P13473 | 0.011818700619699 | 1.19 | 0.042278849036246 |
| CRTAC1 | Cartilage acidic protein 1 | Q9NQ79 | 0.012282687547432 | 1.23 | 0.043191407027815 |
| PCOLCE | Procollagen C-endopeptidase enhancer 1 | Q15113 | 0.012858286614664 | 1.19 | 0.044281235146809 |
| AFM | Afamin | P43652 | 0.014449995361757 | 1.12 | 0.047073156606685 |
| PLG | Plasminogen | P00747 | 0.014808887658904 | 1.14 | 0.047661474616677 |
| COL6A3 | Collagen alpha-3(VI) chain | P12111 | 0.015123384190082 | 1.35 | 0.048165491709375 |
| C7 | Complement component C7 | P10643 | 0.015253718180595 | 1.14 | 0.048371295829491 |
| APOA2 | Apolipoprotein A-II | P02652 | 0.015768184543684 | −1.35 | 0.049166640144774 |
| CD109 | CD109 antigen | Q6YHK3 | 0.016302896370883 | 1.23 | 0.049965576376137 |
| ACTG1 | Actin, cytoplasmic 2 | P63261 | 0.01842844064171 | 1.23 | 0.052893098007721 |
| CD14 | Monocyte differentiation antigen CD14 | P08571 | 0.018648336393252 | 1.14 | 0.05317487598941 |
| KLKB1 | Plasma kallikrein | P03952 | 0.019913520723869 | 1.11 | 0.054727223568396 |
| KNG1 | Kininogen-1 | P01042 | 0.021034485331523 | 1.11 | 0.056011643691759 |
| F5 | Coagulation factor V | P12259 | 0.021375886441285 | 1.14 | 0.056387118262621 |
| SERPINF2 | Alpha-2-antiplasmin | P08697 | 0.024325248700793 | 1.09 | 0.059359684835652 |
| C1S | Complement C1s subcomponent | P09871 | 0.024366317843667 | 1.12 | 0.059397936011767 |
| F2 | Prothrombin | P00734 | 0.024740545362472 | 1.12 | 0.059742847153768 |
| APOA4 | Apolipoprotein A-IV | P06727 | 0.025696265563249 | 1.13 | 0.060594940495585 |
| IGKV2D-40 | Ig kappa chain V-II region TEW | A0A075B6R1 | 0.025902708420233 | −1.20 | 0.060773774727794 |
| LYVE1 | Lymphatic vessel endothelial hyaluronic acid receptor 1 | Q9Y5Y7 | 0.026443478521856 | 1.24 | 0.061233787247234 |
| F13A1 | Coagulation factor XIII A chain | P00488 | 0.027407334083503 | 1.14 | 0.062086047473999 |
| S100A8 | Protein S100-A8 | P05109 | 0.030888403899574 | 1.24 | 0.065695245585865 |
| ANPEP | Aminopeptidase N | P15144 | 0.030918599644144 | 1.22 | 0.065724623760281 |
| VTN | Vitronectin | P04004 | 0.031818887929209 | 1.10 | 0.066586456714209 |
| C4BPA | C4b-binding protein alpha chain | P04003 | 0.034467677540817 | −1.17 | 0.068973446582385 |
| APOH | Beta-2-glycoprotein 1 | P02749 | 0.035328247276582 | 1.13 | 0.06970463250612 |
| C6 | Complement component C6 | P13671 | 0.036921822018089 | 1.10 | 0.071005866471262 |
| C1R | Complement C1r subcomponent | P00736 | 0.03697367472293 | 1.13 | 0.07104710171526 |
| CLU | Clusterin | P10909 | 0.037047254149251 | 1.09 | 0.071105498589918 |
| COMP | Cartilage oligomeric matrix protein | P49747 | 0.038053606817258 | 1.27 | 0.071890746567978 |
| CPN2 | Carboxypeptidase N subunit 2 | P22792 | 0.039032541881775 | 1.11 | 0.07263130677403 |
| ADIPOQ | Adiponectin | Q15848 | 0.041918375605006 | 1.28 | 0.076309890815356 |
| ATRN | Attractin | O75882 | 0.045675287259397 | 1.09 | 0.080866376756604 |
| VASN | Vasorin | Q6EMK4 | 0.047805918283872 | 1.15 | 0.083340993340051 |
| RARRES2 | Retinoic acid receptor responder protein 2 | Q99969 | 0.048852426112363 | 1.15 | 0.084528878416831 |
Note: Label-free discovery proteomic was used to compare age 11 plasma samples from children with an outcome of PD at age 18 with age-matched healthy controls (n = 75). Sixty proteins were identified as significantly differentially expressed between cases and controls (ANCOVA, P < .05), following adjustment for gender and BMI as covariates (supplementary table 1). The gene name, protein name, accession, ANCOVA adjusted P value, fold change (FC) in disorder, and false discovery rate (FDR) values are listed for the 60 significant proteins which are sorted by FDR.